The high-pathogenicity island (HPI) promotes flagellum-mediated motility in extraintestinal pathogenic Escherichia coli.
The key of success of extraintestinal pathogenic Escherichia coli (ExPEC) to colonize niches outside the intestinal tract and to establish infection is the coordinated action of numerous virulence and fitness factors.The so-called high-pathogenicity island (HPI), responsible for synthesis, secretion and cbb5 uptake of the siderophore yersiniabactin